Anastomosis of endothelial sprouts forms new vessels in a tissue analogue of angiogenesis.

@article{Song2012AnastomosisOE,
  title={Anastomosis of endothelial sprouts forms new vessels in a tissue analogue of angiogenesis.},
  author={Jonathan W Song and Despina Bazou and Lance L. Munn},
  journal={Integrative biology : quantitative biosciences from nano to macro},
  year={2012},
  volume={4 8},
  pages={
          857-62
        }
}
Here we describe a microfluidic device that accurately reproduces the dynamics of vascular anastomosis, the process by which vascular sprouts connect to achieve perfusion during angiogenesis. The micro-device features two parallel endothelial cell-lined vessel analogues separated by a 300 μm wide collagenous matrix into which the vessels can sprout and form perfused bridging connections. By accurately recapitulating anastomosis in vitro, the device will enable a new generation of studies of the… CONTINUE READING
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