Anaplastic lymphoma kinase inhibitors as anticancer therapeutics: a patent review.

  title={Anaplastic lymphoma kinase inhibitors as anticancer therapeutics: a patent review.},
  author={Eugen F Mesaros and Gregory R. Ott and Bruce D. Dorsey},
  journal={Expert opinion on therapeutic patents},
  volume={24 4},
INTRODUCTION Anaplastic lymphoma kinase (ALK), a receptor tyrosine kinase from the insulin receptor superfamily, is implicated in the oncogenesis of numerous cancers including anaplastic large-cell lymphoma, non-small-cell lung cancer, diffuse large B-cell lymphoma, inflammatory myofibroblastic tumors, glioblastoma, as well as neuroblastoma. The root cause for these specific cancers has been identified as aberrant ALK kinase activity, which has been shown to be associated with specific gene… CONTINUE READING
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