Anaplastic ameloblastic fibrosarcoma arising from recurrent ameloblastic fibroma: restricted molecular abnormalities of certain genes to the malignant transformation.

@article{Williams2007AnaplasticAF,
  title={Anaplastic ameloblastic fibrosarcoma arising from recurrent ameloblastic fibroma: restricted molecular abnormalities of certain genes to the malignant transformation.},
  author={Michelle D Williams and Ehab Y Hanna and Nikhil Munshi},
  journal={Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics},
  year={2007},
  volume={104 1},
  pages={
          72-5
        }
}
A rare case of anaplastic ameloblastic fibrosarcoma (AS) arising in an ameloblastic fibroma (AF) of the maxilla of a 48-year-old patient 10 years after the primary excision is presented. The recurrent tumor retained focal areas of AF but manifested heterogeneous malignant features ranging from low-grade spindle to highly pleomorphic sarcomas. Biomarker analysis showed alterations of the p53 and c-KIT genes restricted to the sarcomatous component. The biological implications of these findings in… CONTINUE READING
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