Anaplasia in pilocytic astrocytoma predicts aggressive behavior.

  title={Anaplasia in pilocytic astrocytoma predicts aggressive behavior.},
  author={Fausto J Rodriguez and Bernd Walter Scheithauer and Peter C. Burger and Sarah Jenkins and Caterina Giannini},
  journal={The American journal of surgical pathology},
  volume={34 2},
The clinical significance of anaplastic features, a rare event in pilocytic astrocytoma (PA), is not fully established. We reviewed 34 PA with anaplastic features (Male = 21, Female = 13; median age 35 y, 5 to 75) among approximately 2200 PA cases (1.7%). Tumors were included which demonstrated brisk mitotic activity [at least 4 mitoses/10 high power fields (400 x )], in addition to hypercellularity and moderate-to-severe cytologic atypia, with or without necrosis. The tumors either had a PA… CONTINUE READING
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