Anaphylaxis to omeprazole: diagnosis and desensitization protocol.

  title={Anaphylaxis to omeprazole: diagnosis and desensitization protocol.},
  author={Ronit Confino-Cohen and Arnon Goldberg},
  journal={Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology},
  volume={96 1},
BACKGROUND Omeprazole is an inhibitor of the parietal cell enzyme H+/K+ adenosine triphosphatase. Immediate-type hypersensitivity reactions, such as urticaria, angioedema, and hypotension, induced by omeprazole and other proton pump inhibitors are rare. OBJECTIVES To confirm the immediate-type mechanism of recurrent anaphylactic reactions to the repeated administration of omeprazole using skin testing and to enable safe administration of the drug after successful oral desensitization… CONTINUE READING


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