Anaphylaxis caused by repetitive doses of a GITR agonist monoclonal antibody in mice.

@article{Murphy2014AnaphylaxisCB,
  title={Anaphylaxis caused by repetitive doses of a GITR agonist monoclonal antibody in mice.},
  author={Judith Therese Murphy and Andre P Burey and Amy M. Beebe and Danling Gu and Leonard G. Presta and Taha Merghoub and Jedd D Wolchok},
  journal={Blood},
  year={2014},
  volume={123 14},
  pages={
          2172-80
        }
}
Immunotherapy for cancer using antibodies to enhance T-cell function has been successful in recent clinical trials. Many molecules that improve activation and effector function of T cells have been investigated as potential new targets for immunomodulatory antibodies, including the tumor necrosis factor receptor superfamily members GITR and OX40. Antibodies engaging GITR or OX40 result in significant tumor protection in preclinical models. In this study, we observed that the GITR agonist… CONTINUE READING
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