Anaphylatoxin C3a enhances mucous glycoprotein release from human airways in vitro

@article{Marom1985AnaphylatoxinCE,
  title={Anaphylatoxin C3a enhances mucous glycoprotein release from human airways in vitro},
  author={Zvi Marom and James H. Shelhamer and Marjolein Y. Berger and M. Frank and Michael A. Kaliner},
  journal={The Journal of Experimental Medicine},
  year={1985},
  volume={161},
  pages={657 - 668}
}
Because C3a may be generated during the course of pulmonary inflammatory reactions, we investigated the ability of C3a to affect mucous glycoprotein (MGP) secretion from cultured human airways. C3a, but not C3a des Arg, caused a dose-related increase in MGP release (maximal after 4-6 h), with as little as 15 micrograms of C3a per milliliter stimulating a 40% increase. The experimental evidence suggested that immunologically specific C3a was required for the secretagogue actions, as monospecific… CONTINUE READING

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