Anandamide reduces infarct size in rat isolated hearts subjected to ischaemia-reperfusion by a novel cannabinoid mechanism.

@article{Underdown2005AnandamideRI,
  title={Anandamide reduces infarct size in rat isolated hearts subjected to ischaemia-reperfusion by a novel cannabinoid mechanism.},
  author={Nichola J Underdown and C. Robin Hiley and William R. Ford},
  journal={British journal of pharmacology},
  year={2005},
  volume={146 6},
  pages={809-16}
}
Although the endocannabinoids 2-arachidonoylglycerol (2-AG) and anandamide share a similar pharmacology, 2-AG reportedly limits myocardial ischaemia-reperfusion injury whereas anandamide does not. We therefore investigated whether or not anandamide reduces infarct size and which, if any, of the known cannabinoid-signalling pathways are involved. Rat isolated perfused hearts were subjected to global, no-flow ischaemia (30 min) and reperfusion (1 h). Agonists were present from 5 min before… CONTINUE READING

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Anandamide reduces infarct size in rat isolated hearts by a mechanism independent of CB1 or CB2 receptor activation

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