Anandamide modulates sleep and memory in rats.

  title={Anandamide modulates sleep and memory in rats.},
  author={Eric Murillo-Rodr{\'i}guez and Manuel S{\'a}nchez-Alav{\'e}z and Luz Navarro and Dolores Martinez-Gonzalez and Ren{\'e} Drucker-Col{\'i}n and O Prosp{\'e}ro-garc{\'i}a},
  journal={Brain research},
  volume={812 1-2},
In this study we have assessed the effect of the intracerebroventricular administration of anandamide (ANA) as well as its precursor metabolite arachidonic acid (AA), on the sleep-wakefulness cycle, memory formation, locomotor activity and pain perception. Our results have indicated that ANA strikingly increases slow-wave sleep (SWS)2 and rapid-eye movement (REM) sleep at the expense of wakefulness (W); while deteriorating memory consolidation. ANA also increases locomotor activity but does not… CONTINUE READING

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