Anandamide modulates sleep and memory in rats

  title={Anandamide modulates sleep and memory in rats},
  author={Eric Murillo-Rodr{\'i}guez and Manuel S{\'a}nchez-Alavez and Luz Navarro and Dolores Martı́nez-Gonz{\'a}lez and Ren{\'e} Drucker-Col{\'i}n and Oscar E Prospero-Garcia},
  journal={Brain Research},
Modulation of Sleep-Wake Cycles in Mice and Rats with Cannabinoids
The main psychoactive ingredient of marijuana tetrahydrocannabinol and endocannabinoids and their derivatives are involved in the modulation of the sleep-wake cycle, indicating that the effects on sleep are mediated by activation of CB1 receptors.
Oleamide modulates memory in rats
Basic sleep mechanisms: an integrative review.
A broader understanding of the present knowledge in the field of sleep research is provided by the recognition of sleep-promoting molecules that accumulate in the brain in prolonged W as well as the physiological role of gene expression during sleep.
Anandamide-induced sleep is blocked by SR141716A, a CB1 receptor antagonist and by U73122, a phospholipase C inhibitor
The present results suggest that a cannabinoid system in the PPTg may be involved in sleep regulation and that the cannabinoid effect is mediated by the CB1 receptor coupled to a PLC second messenger system.
Anandamide enhances extracellular levels of adenosine and induces sleep: an in vivo microdialysis study.
Anandamide increased adenosine levels in the basal forebrain and also increased sleep in conditions where sleep may be severely attenuated, and this findings identify a potential therapeutic use of endocannabinoids to induce sleep in terms of dosage and mechanism.
REM sleep enhancement induced by different procedures improves memory retention in rats
The results suggest that an experimentally induced increase of PS after learning facilitates memory consolidation, and there was a highly significant correlation between post‐training PS values and retention scores.


Molecular mechanisms of sleep‐wake regulation: roles of prostaglandins D2 and E2
  • O. Hayaishi
  • Biology, Medicine
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 1991
Experimental evidence indicates that prostaglandins D2 and E2 are probably two of the major endogenous sleep‐regulating substances, one promoting sleep and the other wakefulness, in rats, dogs, rabbits, monkeys, and probably in humans as well.
Increases in number of REMS and REM density in humans following an intensive learning period.
Results support the idea of REM sleep and/or the REMs themselves being involved in long-term memory processing several days after the end of training.
A second endogenous cannabinoid that modulates long-term potentiation
2-AG activates neuronal cannabinoid receptors as a full agonist, and prevents the induction of long-term potentiation at CA3–CA1 synapses, indicating that 2-AG is a second endogenous cannabinoid ligand in the central nervous system.
Inhibitors of Cyclooxygenases produce Amnesia for a Passive Avoidance Task in the Chick
  • C. Hölscher
  • Biology, Psychology
    The European journal of neuroscience
  • 1995
The results indicate that cyclooxygenase products, but not lipoxygenases or thromboxane synthase Products, play a role in memory consolidation in the chick when learning this task.