Anandamide may mediate sleep induction

  title={Anandamide may mediate sleep induction},
  author={Raphael Mechoulam and Ester Fride and Lumir Hanu and Tzviel Sheskin and Tiziana Bisogno and Vincenzo Di Marzo and Michael L. Bayewitch and Zvi Vogel},
Behavioral evidence for the interaction of oleamide with multiple neurotransmitter systems.
Interestingly, oleamide analogs resistant to hydrolysis by fatty acid amide hydrolase (FAAH) maintained but did not show increased behavioral potency or duration of action, whereas two FAAH inhibitors produced analogous behavioral effects.
Pharmacological activity of fatty acid amides is regulated, but not mediated, by fatty acid amide hydrolase in vivo.
The results indicate that FAAH is a key regulator, but not mediator of FAA activity in vivo, and suggest that FAAs represent a family of signaling lipids that, despite sharing similar chemical structures and a common pathway for catabolism, produce their behavioral effects through distinct receptor systems in vivo.
The Hypnotic Actions of the Fatty Acid Amide, Oleamide
Effect of Medical Marijuana Card Ownership on Pain, Insomnia, and Affective Disorder Symptoms in Adults
This randomized clinical trial examines the risks and benefits of a medical marijuana card, including the development of cannabis use disorder and improvement of insomnia symptoms.
Cannabis Use and Sleep Quality in Daily Life: a Daily Diary Study of Adults Starting Cannabis for Health Concerns
Cannabis use is associated with same day improvements in self-reported sleep quality, but not pain or depressive symptoms, although sleep improvements occurred in the context of increased frequency of cannabis use, raising the risk for cannabis use disorder.
Assessment of NSAIDs as potential inhibitors of the fatty acid amide hydrolase I (FAAH-1) using three different primary fatty acid amide substrates in vitro
There is potential for study of these compounds as combined FAAH-1-COX inhibitors as well as other drugs to treat pain and inflammation without significant adverse effects.