Anandamide induces apoptosis in human endothelial cells: its regulation system and clinical implications.

@article{Yamaji2003AnandamideIA,
  title={Anandamide induces apoptosis in human endothelial cells: its regulation system and clinical implications.},
  author={Kazuyo Yamaji and Krishna Pada Sarker and Koichi Kawahara and Satoshi Iino and Munekazu Yamakuchi and Kazuhiro Abeyama and Teruto Hashiguchi and Ikuro Maruyama},
  journal={Thrombosis and haemostasis},
  year={2003},
  volume={89 5},
  pages={875-84}
}
Anandamide (AEA), an endogenous cannabinoid, is generated by macrophages during shock conditions, and is thought to be a causative mediator of septic shock. Thus, we hypothesized that AEA plays a crucial role in endothelial cell (EC) injury. Here, we demonstrate that AEA induces apoptosis in a time-and dose-dependent manner in human umbilical vein endothelial cells (HUVECs). AEA triggered phosphorylation of c-Jun NH(2)-terminal kinase (JNK) and p38 mitogen activated protein kinase. AEA also… CONTINUE READING
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Anandamide receptors

  • VD Marzo, LD Petrocellis, F Fezza, A Ligresti, T. Bisogno
  • Prostaglandins Leukot Essent Fatty Acids
  • 2002

The activity of anandamide at vanilloid VR1 receptors requires facilitated transport across the cell membrane and is limited by intracellular metabolism

  • LD Petrocellis, T Bisogno, M Maccarrone, JB Davis, A Finazzi-Agro, VD. Marzo
  • J Biol Chem
  • 2001

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