Anandamide decreases naloxone-precipitated withdrawal signs in mice chronically treated with morphine

@article{Vela1995AnandamideDN,
  title={Anandamide decreases naloxone-precipitated withdrawal signs in mice chronically treated with morphine},
  author={Gregorio Vela and M. Ruiz-gayo and Jos{\'e} Antonio Guti{\'e}rrez Fuentes},
  journal={Neuropharmacology},
  year={1995},
  volume={34},
  pages={665-668}
}
The effect of anandamide, a putative endogenous ligand of the cannabinoid receptor, has been studied in a naloxone-precipitated morphine withdrawal syndrome in mice. Animals were chronically treated with increasing doses of morphine (from 8 to 45 mg/kg) over 5 days or implanted with morphine pellets (72 hr). Typical signs of withdrawal (jumping and body weight loss) were examined after naloxone administration (1 mg/kg). In these conditions, anandamide (5 mg/kg, i.v.) decreased both the number… CONTINUE READING
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