Anandamide and NADA bi-directionally modulate presynaptic Ca2+ levels and transmitter release in the hippocampus.

@article{Kfalvi2007AnandamideAN,
  title={Anandamide and NADA bi-directionally modulate presynaptic Ca2+ levels and transmitter release in the hippocampus.},
  author={Attila K{\"o}falvi and M{\^o}nica Ferreira Pereira and Nelson Rebola and Ricardo J Rodrigues and C R Oliveira and Rodrigo A. Cunha},
  journal={British journal of pharmacology},
  year={2007},
  volume={151 4},
  pages={
          551-63
        }
}
BACKGROUND AND PURPOSE Inhibitory CB(1) cannabinoid receptors and excitatory TRPV(1) vanilloid receptors are abundant in the hippocampus. We tested if two known hybrid endocannabinoid/endovanilloid substances, N-arachidonoyl-dopamine (NADA) and anandamide (AEA), presynapticaly increased or decreased intracellular calcium level ([Ca(2+)](i)) and GABA and glutamate release in the hippocampus. EXPERIMENTAL APPROACH Resting and K(+)-evoked levels of [Ca(2+)](i) and the release of [(3)H]GABA and… CONTINUE READING

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