Anandamide, a natural ligand for the peripheral cannabinoid receptor is a novel synergistic growth factor for hematopoietic cells.

  title={Anandamide, a natural ligand for the peripheral cannabinoid receptor is a novel synergistic growth factor for hematopoietic cells.},
  author={Peter J. M. Valk and Sandra E Verbakel and Yoeri Vankan and Samantha Hol and Shanta Mancham and R Ploemacher and A Mayen and Bob L{\"o}wenberg and Ruud Delwel},
  volume={90 4},
We recently demonstrated that the gene encoding the peripheral cannabinoid receptor (Cb2) may be a proto-oncogene involved in murine myeloid leukemias. We show here that Cb2 may have a role in hematopoietic development. RNAse protection analysis showed that Cb2 is normally expressed in spleen and thymus. Cb2 mRNA is also expressed in 45 of 51 cell lines of distinct hematopoietic lineages, ie, myeloid, macrophage, mast, B-lymphoid, T-lymphoid, and erythroid cells. The effect of the fatty acid… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 49 extracted citations


Publications referenced by this paper.
Showing 1-10 of 29 references

Activation of the human peripheral cannabinoid receptor results in inhibition of adenylylon cells of a thymoma cell line

  • DM Slipetz, GP O’Neal, +5 authors KM Metters
  • J Immunol
  • 1996

NL: Differenti- cannabinoid receptor

  • AW Harris, AD Bankhurst, S Mason, Warner
  • Biochem Biophys Acta 1307:132,
  • 1996

A transplantable myelo- sitivity to anandamide and palmitoylethanolamide

  • NL Warner, MAS Moore, D Metcalf
  • Proc Natl Acad Sci USA
  • 1995

Krox - 24 expression in human Astroma cells

  • T VanBiesen, BE Hawes, +15 authors P Casellas
  • J Biol Chem
  • 1995

NL: Cell cycle related heterogeneity of Ia antigen expression on a murine B lymphoma cell line: Analysis NY, Plenum

  • LL Lanier, Warner
  • 1995

sine-kinase- and G-mediated MAP kinase activation by a common signalling pathway

  • M Bouaboula, C Poinot-Chazel, +6 authors P Casellas
  • Nature 376:781,
  • 1995

Reticulum cell sarcoma: An modulation by cannabinoids

  • P Ralph, J Prichard, M Cohn
  • J Pharmacol Exp Ther 268:1612,
  • 1994

Stimulation of cannabinoid receptor Cb1 induces AMP induced G1 phase arrest mediated by an inhibitor (p27) of cyclin dependent kinase 4 activation

  • M Bouaboula, B Bourrie, M Rinaldi-Carmona, D Shire, G Le Fur, P Casellas
  • Cell 79:487,
  • 1994

Similar Papers

Loading similar papers…