Analyzing the validity of GalR1 and GalR2 antibodies using knockout mice

@article{Lu2009AnalyzingTV,
  title={Analyzing the validity of GalR1 and GalR2 antibodies using knockout mice},
  author={Xiaoying Lu and Tamas Bartfai},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={2009},
  volume={379},
  pages={417-420}
}
G-protein-coupled receptors (GPCRs) comprise the largest family of cell surface receptors and are the major drug targets for the treatment of various human diseases. The lack of sensitive and selective antibodies capable of recognizing endogenous GPCRs, however, hampers the progress of research on this class of receptors. GalR1 through GalR3, GPCRs for the neuropeptide galanin, are potential drug targets for seizure, Alzheimer’s disease, depression and anxiety, as well as pain and metabolic… CONTINUE READING