Analyzing the functions and structure of the human lipodystrophy protein seipin.

Abstract

Disruption of the gene BSCL2, which encodes the protein seipin, causes severe generalized lipodystrophy in humans with a near complete absence of adipose tissue. Moreover, cell culture studies have demonstrated that seipin plays a critical cell-autonomous role in adipocyte differentiation. These observations reveal seipin as a critical regulator of human… (More)
DOI: 10.1016/B978-0-12-411619-1.00009-4

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Cite this paper

@article{Sim2014AnalyzingTF, title={Analyzing the functions and structure of the human lipodystrophy protein seipin.}, author={M. F. Michelle Sim and Mesbah Uddin Talukder and Rowena J. Dennis and J. Michael Edwardson and Justin J. Rochford}, journal={Methods in enzymology}, year={2014}, volume={537}, pages={161-75} }