Analyzing primary Hodgkin and Reed-Sternberg cells to capture the molecular and cellular pathogenesis of classical Hodgkin lymphoma.

@article{Tiacci2012AnalyzingPH,
  title={Analyzing primary Hodgkin and Reed-Sternberg cells to capture the molecular and cellular pathogenesis of classical Hodgkin lymphoma.},
  author={Enrico Tiacci and Claudia D{\"o}ring and Verena Brune and Carel J M van Noesel and Wolfram Klapper and Gunhild Mechtersheimer and Brunangelo Falini and Ralf K{\"u}ppers and Martin-Leo Hansmann},
  journal={Blood},
  year={2012},
  volume={120 23},
  pages={4609-20}
}
The pathogenesis of classical Hodgkin lymphoma (cHL), the most common lymphoma in the young, is still enigmatic, largely because its Hodgkin and Reed-Sternberg (HRS) tumor cells are rare in the involved lymph node and therefore difficult to analyze. Here, by overcoming this technical challenge and performing, for the first time, a genome-wide transcriptional analysis of microdissected HRS cells compared with other B-cell lymphomas, cHL lines, and normal B-cell subsets, we show that they differ… CONTINUE READING

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