Analyzing mechanism(s) of hallucinogenic drug action with drug discrimination procedures

@article{Appel1982AnalyzingMO,
  title={Analyzing mechanism(s) of hallucinogenic drug action with drug discrimination procedures},
  author={James B. Appel and Francis J. White and Alice Marie Holohean},
  journal={Neuroscience & Biobehavioral Reviews},
  year={1982},
  volume={6},
  pages={529-536}
}

• James B. Appel, Francis J. White, Alice Marie Holohean
• Published 1982 in Neuroscience & Biobehavioral Reviews
• DOI:10.1016/0149-7634(82)90036-7

Some of the advantages of using drug discrimination (DD) procedure to analyze the mechanisms of action of hallucinogenic and related drugs were illustrated by reviewing research with lysergic acid diethylamide (LSD). Because they ensure that drug-induced alterations in interoceptive "state" become biologically meaningful "cues," these procedures are reliable, robust, sensitive and specific. With reference to LSD, many DD experiments suggest: (1) that while hallucinogens substitute for (mimic… CONTINUE READING

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