Analyzing mast cell development and function using mice carrying mutations at W/c-kit or Sl/MGF (SCF) loci.

@article{Galli1992AnalyzingMC,
  title={Analyzing mast cell development and function using mice carrying mutations at W/c-kit or Sl/MGF (SCF) loci.},
  author={Stephen J. Galli and Mindy Tsai and John R. M. Gordon and E. N. Geissler and Barry K. Wershil},
  journal={Annals of the New York Academy of Sciences},
  year={1992},
  volume={664},
  pages={69-88}
}
Mast cells have been implicated in a wide variety of biological responses, but identifying the nature and importance of the mast cell's specific contributions to these reactions has been difficult. W/Wv mice have mutations affecting the c-kit tyrosine kinase receptor which is encoded at the W locus and which is necessary for normal mast cell development. In W/Wv mice, the cells which ordinarily give rise to normal mast cell populations do not adequately respond to a major migration, survival… CONTINUE READING

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