Analyzing heat capacity profiles of peptide-containing membranes: cluster formation of gramicidin A.

@article{Ivanova2003AnalyzingHC,
  title={Analyzing heat capacity profiles of peptide-containing membranes: cluster formation of gramicidin A.},
  author={Vesselka P Ivanova and I M Makarov and Tilman E. Sch{\"a}ffer and T Heimburg},
  journal={Biophysical journal},
  year={2003},
  volume={84 4},
  pages={2427-39}
}
The analysis of peptide and protein partitioning in lipid membranes is of high relevance for the understanding of biomembrane function. We used statistical thermodynamics analysis to demonstrate the effect of peptide mixing behavior on heat capacity profiles of lipid membranes with the aim to predict peptide aggregation from c(P)-profiles. This analysis was applied to interpret calorimetric data on the interaction of the antibiotic peptide gramicidin A with lipid membranes. The shape of the… CONTINUE READING

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