Analytical reduction of combinatorial complexity arising from multiple protein modification sites.

Abstract

Combinatorial complexity is a major obstacle to ordinary differential equation (ODE) modelling of biochemical networks. For example, a protein with 10 sites that can each be unphosphorylated, phosphorylated or bound to adaptor protein requires 3(10) ODEs. This problem is often dealt with by making ad hoc assumptions which have unclear validity and disallow… (More)
DOI: 10.1098/rsif.2014.1215

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