Analytical methodologies for the enantiodetermination of citalopram and its metabolites.

@article{Budu2019AnalyticalMF,
  title={Analytical methodologies for the enantiodetermination of citalopram and its metabolites.},
  author={Monica Budău and Gabriel Hancu and Aura Rusu and Daniela-Lucia Muntean},
  journal={Chirality},
  year={2019}
}
Citalopram (CIT) is a highly selective serotonin reuptake inhibitor (SSRI) frequently used in the treatment of major depressive disorders. It has a chiral centre in its structure and is used in therapy both as a racemic mixture (R,S-CIT) and a pure enantiomer (S-CIT). The differences between the pharmacokinetic and pharmacological profiles of the two enantiomers are well established. Consequently, the development of new efficient chiral analysis methods for their enantiomeric separation is a… 
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