Analytical method development and validation of mianserin hydrochloride and its metabolite in human plasma by LC-MS.

@article{Chauhan2005AnalyticalMD,
  title={Analytical method development and validation of mianserin hydrochloride and its metabolite in human plasma by LC-MS.},
  author={Bhupendrasinh Chauhan and Shubha Rani and Swati Guttikar and Anjali Zope and Nimisha Jadon and Harish Padh},
  journal={Journal of chromatography. B, Analytical technologies in the biomedical and life sciences},
  year={2005},
  volume={823 2},
  pages={69-74}
}
Mianserin is a tetracyclic antidepressant drug and administered as racemate of R (-) and S (+) mianserin hydrochloride in a dose of 30-90 mg/day in divided doses. Liquid chromatography-mass spectroscopy (LC-MS) is a tool, which is widely used for determination of drug and their metabolites in biological fluids because of its high sensitivity and precision. Here we describe a liquid chromatography mass spectroscopy method for simultaneous determination of mianserin and its metabolite, N… CONTINUE READING