Analytical fractionation of human liver microsomal fractions: localization of cholesterol and of the enzymes relevant to its metabolism.

@article{Balasubramaniam1981AnalyticalFO,
  title={Analytical fractionation of human liver microsomal fractions: localization of cholesterol and of the enzymes relevant to its metabolism.},
  author={Srikant Balasubramaniam and K A. Mitropoulos and Soundararajan Venkatesan and Nicolas B Myant and Timothy J. Peters and Alfredo Postiglione and Mario Mancini},
  journal={Clinical science},
  year={1981},
  volume={60 4},
  pages={435-9}
}
1. The submicrosomal distribution of three enzymes concerned in cholesterol metabolism, and of free and esterified cholesterol, was determined in human liver by analytical isopycnic centrifugation on sucrose gradients. 2. The distribution profile and median density of acyl-CoA:cholesterol O-acyltransferase was similar to that of RNA, showing that this enzyme is confined largely to the ribosome-rich membranes of the endoplasmic reticulum. The distribution profiles and median densities of 3… CONTINUE READING

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