Analytical description of the activation of multi-state receptors by continuous neurotransmitter signals at brain synapses.

@article{Uteshev1997AnalyticalDO,
  title={Analytical description of the activation of multi-state receptors by continuous neurotransmitter signals at brain synapses.},
  author={V V Uteshev and Peter S. Pennefather},
  journal={Biophysical journal},
  year={1997},
  volume={72 3},
  pages={1127-34}
}
Chemical synaptic transmission is a fundamental component of interneuronal communications in the central nervous system (CNS). Discharge of a presynaptic vesicle containing a few thousand molecules (a quantum) of neurotransmitter into the synaptic cleft generates a transmitter concentration signal that drives postsynaptic ion-channel receptors. These receptors exhibit multiple states, with state transition kinetics dependent on neurotransmitter concentration. Here, a novel and simple analytical… CONTINUE READING
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