Analytical approximation to the accessible surface area of proteins.

  title={Analytical approximation to the accessible surface area of proteins.},
  author={Shoshana J. Wodak and Jo{\"e}l Janin},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={77 4},
We propose an analytical substitute to the geometrical construction that is commonly used in calculating the protein surface area that is accessible to the solvent. A statistical approach leads to an expression of accessible surface areas as a function of distances between pairs of atoms or of residues in the protein structure, assuming only that these atoms or residues are randomly distributed in space but not penetrating each other. This function gives good estimates of the accessible surface… CONTINUE READING

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