Analytical and semipreparative resolution of ranolazine enantiomers by liquid chromatography using polysaccharide chiral stationary phases.

@article{Luo2006AnalyticalAS,
  title={Analytical and semipreparative resolution of ranolazine enantiomers by liquid chromatography using polysaccharide chiral stationary phases.},
  author={Xingping Luo and Zongde Zhai and Xiaomei Wu and Yan-Ping Shi and Liren Chen and Yongmin Li},
  journal={Journal of separation science},
  year={2006},
  volume={29 1},
  pages={164-71}
}
Novel HPLC methods were developed for the analytical and semipreparative resolution of new antianginal drug ranolazine enantiomers. Good baseline enantioseparation was achieved using cellulose tris (3,5-dimethylphenylcarbamate) (CDMPC) chiral stationary phases (CSPs) under both normal-phase and polar organic modes. The validation of the analytical methods including linearity, LODs, recovery, and precision, and the semipreparative resolution of ranolazine racemate were carried out using methanol… CONTINUE READING