Analytical and Clinical Validation of a Digital Sequencing Panel for Quantitative, Highly Accurate Evaluation of Cell-Free Circulating Tumor DNA

@inproceedings{Lanman2015AnalyticalAC,
  title={Analytical and Clinical Validation of a Digital Sequencing Panel for Quantitative, Highly Accurate Evaluation of Cell-Free Circulating Tumor DNA},
  author={Richard B. Lanman and Stefanie A W Mortimer and Oliver A. Zill and Dragan Sebisanovic and Ren{\'e} L{\'o}pez and Sibel Blau and Eric A. Collisson and Stephen G. Divers and Dave S B Hoon and Edmund S Kopetz and Jeeyun Lee and Petros G. Nikolinakos and Arthur M. Baca and Bahram Ghaffarzadeh Kermani and Helmy Eltoukhy and Amirali Talasaz and J{\"o}rg D. Hoheisel},
  booktitle={PloS one},
  year={2015}
}
Next-generation sequencing of cell-free circulating solid tumor DNA addresses two challenges in contemporary cancer care. First this method of massively parallel and deep sequencing enables assessment of a comprehensive panel of genomic targets from a single sample, and second, it obviates the need for repeat invasive tissue biopsies. Digital Sequencing™ is a novel method for high-quality sequencing of circulating tumor DNA simultaneously across a comprehensive panel of over 50 cancer-related… CONTINUE READING
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Broad, hybrid capture-based next-generation sequencing identifies actionable genomic alterations in “driver-negative” lung adenocarcinomas

  • A Drilon, L Wang, ME Arcila, S Balasubramanian, JR Greenbowe, JS Ross
  • Clin Cancer Res Off J Am Assoc Cancer Res
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