Analytical Method Development and Validation for HPLC-ECD Determination of Moxifloxacin in Marketed Formulations

@article{Reddy2018AnalyticalMD,
  title={Analytical Method Development and Validation for HPLC-ECD Determination of Moxifloxacin in Marketed Formulations},
  author={G. Phani Sekhar Reddy and K. Navyasree and P. Jagadish and K. Bhat},
  journal={Pharmaceutical Chemistry Journal},
  year={2018},
  volume={52},
  pages={674-679}
}
An HPLC-ECD analytical method with high reproducibility and wide linearity range has been developed and validated. Moxifloxacin was separated and identified using this method with a simple mobile phase comprising Britton Robinson buffer pH 5.0 and methanol (93: 7 v/v) flowing at a rate of 0.5 mL/min through Acclaim C18 column (150 mm × 4.6 mm × 5 im) maintained at 35°C and detected at redox potential value of 1.0 V. The LOD and LOQ were found to be 2.2 and 6.6 μg/mL, respectively. The HPLC-ECD… Expand

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