Analytical Interference by Contrast Agents in Biochemical Assays

  title={Analytical Interference by Contrast Agents in Biochemical Assays},
  author={Sigrid Otnes and Niels Fogh‐Andersen and Janne R{\o}msing and Henrik S. Thomsen},
  journal={Contrast Media \& Molecular Imaging},
Objective To provide a clinically relevant overview of the analytical interference by contrast agents (CA) in laboratory blood test measurements. Materials and Methods The effects of five CAs, gadobutrol, gadoterate meglumine, gadoxetate disodium, iodixanol, and iomeprol, were studied on the 29 most frequently performed biochemical assays. One-day-old plasma, serum, and whole blood were spiked with doses of each agent such that the gadolinium agents and the iodine agents reached concentrations… 

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