Analytical Challenges: Determination of Tetrodotoxin in Human Urine and Plasma by LC-MS/MS

  title={Analytical Challenges: Determination of Tetrodotoxin in Human Urine and Plasma by LC-MS/MS},
  author={Kelvin Sze-Yin Leung and Bonnie Mei-wah Fong and Y. H. Tsoi},
  booktitle={Marine drugs},
Tetrodotoxin (TTX) is a powerful sodium channel blocker found in puffer fish and some marine animals. Cases of TTX poisoning most often result from puffer fish ingestion. Diagnosis is mainly from patient's signs and symptoms or the detection of TTX in the leftover food. If leftover food is unavailable, the determination of TTX in the patient's urine and/or plasma is essential to confirm the diagnosis. Although various methods for the determination of TTX have been published, most of them are… CONTINUE READING


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