Analysis of volatile disease markers in blood.

  title={Analysis of volatile disease markers in blood.},
  author={Wolfram Miekisch and Jochen K. Schubert and Dierk A. Vagts and Klaus Geiger},
  journal={Clinical chemistry},
  volume={47 6},
BACKGROUND The diagnostic potential of breath analysis has been limited by a lack of knowledge on origin, distribution, and metabolism of the exhaled substances. To overcome this problem, we developed a method to assess trace amounts of hydrocarbons (pentane and isoprene), ketones (acetone), halogenated compounds (isoflurane), and thioethers (dimethyl sulfide) in the blood of humans and animals. METHODS Arterial and venous blood samples were taken from mechanically ventilated patients… CONTINUE READING