Analysis of vitamin D-regulated gene expression in LNCaP human prostate cancer cells using cDNA microarrays.

@article{Krishnan2004AnalysisOV,
  title={Analysis of vitamin D-regulated gene expression in LNCaP human prostate cancer cells using cDNA microarrays.},
  author={Aruna V. Krishnan and Rajesh Shinghal and Nalini Raghavachari and James D Brooks and Donna M. Peehl and David Feldman},
  journal={The Prostate},
  year={2004},
  volume={59 3},
  pages={243-51}
}
BACKGROUND 1,25-dihydroxyvitamin D(3) [1,25(OH)2D3] exerts growth inhibitory, pro-differentiating, and pro-apoptotic effects on prostate cells. To better understand the molecular mechanisms underlying these actions, we employed cDNA microarrays to study 1,25(OH)2D3-regulated gene expression in the LNCaP human prostate cancer cells. METHODS mRNA isolated from LNCaP cells treated with vehicle or 50 nM 1,25(OH)2D3 for various lengths of time were hybridized to microarrays carrying approximately… CONTINUE READING

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