Analysis of vinyl acetate metabolism in rat and human nasal tissues by an in vitro gas uptake technique.

@article{Bogdanffy1998AnalysisOV,
  title={Analysis of vinyl acetate metabolism in rat and human nasal tissues by an in vitro gas uptake technique.},
  author={Matthew S. Bogdanffy and Ramesh Sarangapani and Julia S. Kimbell and Steven R. Frame and David R. Plowchalk},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={1998},
  volume={46 2},
  pages={235-46}
}
Physiologically based pharmacokinetic (PBPK) models require estimates of catalytic rate constants controlling the metabolism of xenobiotics. Usually, these constants are derived from whole tissue homogenates wherein cellular architecture and enzyme compartmentation are destroyed. Since the nasal cavity epithelium is composed of a heterogeneous cell population measurement of xenobiotic metabolizing enzymes using homogenates could yield artifactual results. In this article a method for measuring… CONTINUE READING

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