Analysis of untyped SNPs: maximum likelihood and imputation methods.

@article{Hu2010AnalysisOU,
  title={Analysis of untyped SNPs: maximum likelihood and imputation methods.},
  author={Yijuan Hu and Dan-Yu Lin},
  journal={Genetic epidemiology},
  year={2010},
  volume={34 8},
  pages={803-15}
}
Analysis of untyped single nucleotide polymorphisms (SNPs) can facilitate the localization of disease-causing variants and permit meta-analysis of association studies with different genotyping platforms. We present two approaches for using the linkage disequilibrium structure of an external reference panel to infer the unknown value of an untyped SNP from the observed genotypes of typed SNPs. The maximum-likelihood approach integrates the prediction of untyped genotypes and estimation of… CONTINUE READING
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