Analysis of two domains with novel RNA-processing activities throws light on the complex evolution of ribosomal RNA biogenesis

@inproceedings{Burroughs2014AnalysisOT,
  title={Analysis of two domains with novel RNA-processing activities throws light on the complex evolution of ribosomal RNA biogenesis},
  author={A. Maxwell Burroughs and L. Aravind},
  booktitle={Front. Genet.},
  year={2014}
}
Ribosomal biogenesis has been extensively investigated, especially to identify the elusive nucleases and cofactors involved in the complex rRNA processing events in eukaryotes. Large-scale screens in yeast identified two biochemically uncharacterized proteins, TSR3 and TSR4, as being key players required for rRNA maturation. Using multiple computational approaches we identify the conserved domains comprising these proteins and establish sequence and structural features providing novel insights… CONTINUE READING
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