Analysis of tumour gene expression following chemotherapeutic treatment of patients with bowel cancer

@article{Clarke1999AnalysisOT,
  title={Analysis of tumour gene expression following chemotherapeutic treatment of patients with bowel cancer},
  author={Paul A Clarke and Mark George and D. Hamish Cunningham and Ian Swift and Paul Workman},
  journal={Nature Genetics},
  year={1999},
  volume={23 Suppl 1},
  pages={39-39}
}
TRAIL is a member of the Tumour Necrosis Factor (TNF) Family and a potent inducer of apoptosis in many breast carcinoma cell lines but not in normal human mammary epithelial cells. In vivo administration of soluble TRAIL causes regression of breast cancer xenografts without causing measurable toxicity. Combining it with other traditional anti-cancer therapies enhances the efficacy of TRAIL treatment. The basis for the resistance of normal breast epithelial cells to TRAILinduced apoptosis will… CONTINUE READING
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