Highly Influenced

# Analysis of tumor as an inverse problem provides a novel theoretical framework for understanding tumor biology and therapy

@article{Gatenby2002AnalysisOT, title={Analysis of tumor as an inverse problem provides a novel theoretical framework for understanding tumor biology and therapy}, author={Robert A. Gatenby and Philip K. Maini and Edward T. Gawlinski}, journal={Appl. Math. Lett.}, year={2002}, volume={15}, pages={339-345} }

- Published 2002 in Appl. Math. Lett.
DOI:10.1016/S0893-9659(01)00141-0

-We use a novel "inverse problem" technique to construct a basic mathematical model of the interacting populations at the tumor-host interface. This approach assumes that invasive cancer is a solution to the set of state equations that govern the interactions of transformed and normal cells. By considering the invading tumor edge as a traveling wave, the general form of the state equations can be inferred. The stability of this traveling wave solution imposes constraints on key biological… CONTINUE READING

#### From This Paper

##### Topics from this paper.

7 Citations

22 References

Similar Papers