Analysis of tumor as an inverse problem provides a novel theoretical framework for understanding tumor biology and therapy

@article{Gatenby2002AnalysisOT,
  title={Analysis of tumor as an inverse problem provides a novel theoretical framework for understanding tumor biology and therapy},
  author={Robert A. Gatenby and Philip K. Maini and Edward T. Gawlinski},
  journal={Appl. Math. Lett.},
  year={2002},
  volume={15},
  pages={339-345}
}
-We use a novel "inverse problem" technique to construct a basic mathematical model of the interacting populations at the tumor-host interface. This approach assumes that invasive cancer is a solution to the set of state equations that govern the interactions of transformed and normal cells. By considering the invading tumor edge as a traveling wave, the general form of the state equations can be inferred. The stability of this traveling wave solution imposes constraints on key biological… CONTINUE READING
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