Analysis of transient and reversible effects of poly-L-arginine on the in vivo nasal absorption of FITC-dextran in rats.

We have investigated whether poly-L-arginine, with a mean molecular weights of 8.9 and 45.5 kDa (poly-L-Arg (10) and poly-L-Arg (50)), can induce transient and reversible effects involving enhancement of the nasal absorption of fluorescein isothiocyanate-labeled dextran (MW 4.4 kDa, FD-4) and determined the main pathway for the increased transport of FD-4… CONTINUE READING