Analysis of transcriptional profiles and functional clustering of global cerebellar gene expression in PCD3J mice.


The Purkinje cell degeneration (PCD) mutant mouse is characterized by a degeneration of cerebellar Purkinje cells and progressive ataxia. To identify the molecular mechanisms that lead to the death of Purkinje neurons in PCD mice, we used Affymetrix microarray technology to compare cerebellar gene expression profiles in pcd3J mutant mice 14 days of age… (More)
DOI: 10.1016/j.bbrc.2008.10.033


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