Analysis of tissue-specific gene delivery by recombinant adenoviruses containing cardiac-specific promoters

@inproceedings{Franz1997AnalysisOT,
  title={Analysis of tissue-specific gene delivery by recombinant adenoviruses containing cardiac-specific promoters},
  author={Wolfgang-M. Franz and Thomas Rothmann and Norbert Frey and Hugo A. Katus},
  year={1997}
}
Objective: To approach heart muscle diseases by gene transfer, an adenoviral vector system was intended to be established suitable for gene expression in ventricular and/or atrial myocardium. Methods: Two adenoviral vectors (Ad-mhcLuc, Ad-mlcLuc) were constructed, in which the luciferase reporter gene is under control of either the ventricle-specific myosin light chain-2 (mlc-2v) or the atrial- and ventricular-specific α -myosin heavy chain ( α -mhc) promoter. For controls, a recombinant… CONTINUE READING

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 41 CITATIONS

Preservation of myocardial function after adenoviral gene transfer in isolated myocardium.

  • American journal of physiology. Heart and circulatory physiology
  • 2000
VIEW 4 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED