Analysis of time trends in adaptive designs with application to a neurophysiology experiment.

@article{Hu2000AnalysisOT,
  title={Analysis of time trends in adaptive designs with application to a neurophysiology experiment.},
  author={F F Hu and William F Rosenberger},
  journal={Statistics in medicine},
  year={2000},
  volume={19 15},
  pages={2067-75}
}
Time trends are present in many sequential experiments. Adaptive designs use accruing data to select future design points. It has been observed that the presence of time trends in adaptive designs can bias results of the study. We propose one method of dealing with time trends in analysing adaptive designs. The method, relevance weighted likelihood, weights individual components of the likelihood differently. Consequently, one can downweight earlier data if there is a clear time trend that… CONTINUE READING