Analysis of the zebrafish smoothened mutant reveals conserved and divergent functions of hedgehog activity.

@article{Chen2001AnalysisOT,
  title={Analysis of the zebrafish smoothened mutant reveals conserved and divergent functions of hedgehog activity.},
  author={Wenbiao Chen and Shawn Burgess and Nancy Hopkins},
  journal={Development},
  year={2001},
  volume={128 12},
  pages={2385-96}
}
Despite extensive studies, there are still many unanswered questions regarding the mechanism of hedgehog signaling and the phylogenic conservation of hedgehog function in vertebrates. For example, whether hedgehog signaling in vertebrates requires smoothened is unclear, and the role of hedgehog activity in zebrafish is controversial. We show that inactivation of smoothened by retroviral insertions in zebrafish results in defects that are characteristic of hedgehog deficiencies, including… CONTINUE READING
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