Analysis of the viral elements required in the nuclear import of HIV-1 DNA.

@article{Rivire2010AnalysisOT,
  title={Analysis of the viral elements required in the nuclear import of HIV-1 DNA.},
  author={Lise Rivi{\`e}re and J. -L. Darlix and Andrea Cimarelli},
  journal={Journal of virology},
  year={2010},
  volume={84 2},
  pages={729-39}
}
HIV-1 possesses an exquisite ability to infect cells independently from their cycling status by undergoing an active phase of nuclear import through the nuclear pore. This property has been ascribed to the presence of karyophilic elements present in viral nucleoprotein complexes, such as the matrix protein (MA); Vpr; the integrase (IN); and a cis-acting structure present in the newly synthesized DNA, the DNA flap. However, their role in nuclear import remains controversial at best. In the… CONTINUE READING