Analysis of the upstream elements of the xenobiotic compound-inducible and positionally regulated glutathione S-transferase Ya gene.

@article{Paulson1990AnalysisOT,
  title={Analysis of the upstream elements of the xenobiotic compound-inducible and positionally regulated glutathione S-transferase Ya gene.},
  author={K. E. Paulson and J. E. Darnell and Tom H. Rushmore and Cecil B. Pickett},
  journal={Molecular and cellular biology},
  year={1990},
  volume={10 5},
  pages={1841-52}
}
In situ hybridization and other data showed that all hepatocytes express glutathione-S-transferase (GST) Ya mRNA but that specifically pericentral cells can be induced 15- to 20-fold with 3-methylcholanthrene (3-MC). In order to identify DNA sequences involved in inducible expression (pericentral hepatocytes) and constitutive expression (all hepatocytes), the upstream regions of the GST Ya gene were further analyzed by transient transfection and DNA-binding studies to identify the nature of… CONTINUE READING