Analysis of the tyrosine kinome in melanoma reveals recurrent mutations in ERBB4

@article{Prickett2009AnalysisOT,
  title={Analysis of the tyrosine kinome in melanoma reveals recurrent mutations in ERBB4},
  author={Todd D. Prickett and Neena Stephanie Agrawal and Xiaomu Wei and Kristin E. Yates and Jimmy Cheng-Ho Lin and John R. Wunderlich and Julia C. Cronin and P. Cruz and Steven A Rosenberg and Yardena Samuels},
  journal={Nature Genetics},
  year={2009},
  volume={41},
  pages={1127-1132}
}
Tyrosine phosphorylation is important in signaling pathways underlying tumorigenesis. We performed a mutational analysis of the protein tyrosine kinase (PTK) gene family in cutaneous metastatic melanoma. We identified 30 somatic mutations affecting the kinase domains of 19 PTKs and subsequently evaluated the entire coding regions of the genes encoding these 19 PTKs for somatic mutations in 79 melanoma samples. We found ERBB4 mutations in 19% of individuals with melanoma and found mutations in… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 28 references

Analysis of the matrix metalloproteinase family reveals that MMP8 is often mutated in melanoma

  • Palavalli, L.H
  • Nat. Genet
  • 2009

Mechanism of activation and inhibition of the HER4/ErbB4 kinase

  • C Qiu
  • Structure 16,
  • 2008

insights into mechanisms of signal transduction and tumorigenesis

  • Riese, D. J., R. M. Gallo, Settleman, J. Mutational activation of ErbB family receptor tyro kinases
  • Bioessays 29, 558–565
  • 2007