Analysis of the transforming growth factor-beta1 (TGF-beta1) codon 25 gene polymorphism by LightCycler-analysis in patients with chronic hepatitis C infection.

@article{Tag2003AnalysisOT,
  title={Analysis of the transforming growth factor-beta1 (TGF-beta1) codon 25 gene polymorphism by LightCycler-analysis in patients with chronic hepatitis C infection.},
  author={Carmen Gabriele Tag and Senait Mengsteab and Claus Hellerbrand and Frank Lammert and Axel M. Gressner and Ralf Weiskirchen},
  journal={Cytokine},
  year={2003},
  volume={24 5},
  pages={173-81}
}
The polymorphism at position 25 of the gene encoding transforming growth factor-beta1 (TGF-beta1), which changes the amino acid sequence of the signal peptide sequence (arginine to proline), is causing a variation in TGF-beta1 production. The homozygous genotype (Arg25Arg) is associated with higher TGF-beta1 production than the heterozygous (Arg25Pro… CONTINUE READING