Analysis of the stress effects of endocrine disrupting chemicals (EDcs) on Escherichia coli.

Abstract

In this study, three of the representative EDCs, 17beta-estradiol, bisphenol A, and styrene, were employed to find their mode of toxic actions in E. coli. To accomplish this, four different stress response genes, recA, katG, fabA, and grpE genes, were used as a representative for DNA, oxidative, membrane, or protein damage, respectively. The expression levels of these four genes were quantified using a real-time RT-PCR after challenge with three different EDCs individually. Bisphenol A and styrene caused high-level expression of recA and katG genes, respectively, whereas 17beta-estradiol made no significant changes in expression of any of those genes. These results lead to the classification of the mode of toxic actions of EDCs on E. coli.

Cite this paper

@article{Kim2007AnalysisOT, title={Analysis of the stress effects of endocrine disrupting chemicals (EDcs) on Escherichia coli.}, author={Yeon Seok Kim and Jiho Min and Han Na Hongz and Ji Hyun Park and Kyeong Seo Park and Man Bock Gu}, journal={Journal of microbiology and biotechnology}, year={2007}, volume={17 8}, pages={1390-3} }