Analysis of the solution conformations of T4 lysozyme by paramagnetic NMR spectroscopy.


A large number of crystal structures of bacteriophage T4 lysozyme (T4-L) have shown that it contains two subdomains, which can arrange in a compact conformation (closed state) or, in mutants of T4-L, more extended structures (open state). In solution, wild-type T4-L displays only a single set of nuclear magnetic resonance (NMR) signals, masking any… (More)
DOI: 10.1039/c5cp07196h


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